Tottenham Hotspur vs Villarreal Prediction: Muani to be the main man for Spurs

 | Tuesday 16th September 2025, 6:03am

Tuesday 16th September 2025, 6:03am

The Champions League anthem returns to the Tottenham Hotspur Stadium on Tuesday as Spurs play host to Villarreal and fresh off their Europa League success just four months ago, new manager Thomas Frank and his players are now preparing to mix it with Europe's heavyweights. 

Whether you can place Villarreal in that category can be argued but at the same time the famous footballing Yellow Submarine loves nothing more than sinking opponents who do not take them seriously. Both sides keen to get off to a perfect start, both sides know this cannot be the case. Here are my two top tips and my Tottenham Hotspur Predictions for Betfred Insights and check out some of our Price Boosts for the match at the bottom of the article...

Tottenham Hotspur vs Villarreal Betting Tips

  • Randal Kolo-Muani to score anytime @ 7/5
  • Tottenham to win to nil @ 11/5 

*Odds correct as of the time of publication

*For all of our Football Odds then head on over to betfred.com

Team News  

Tottenham's reward for winning the Europa League in May was a golden ticket to this season's Champions League and because of that lofty status, there is no doubt the North London side have become a far greater attraction when it comes to recruiting some of Europe's hottest talents. 

Which means the pair of Xavi Simons and Randal Kolo-Muani are in line to make their European debuts for Spurs and with plenty of excitement attached to the arrival of the pair, they will be tasked with turning that excitement into goals at the expense of La Liga outfit Villarreal.  

As for Tuesday's visitors, their attack is likely to be spearheaded by former Arsenal record signing Nicolas Pepe and new summer capture Georges Mikautuadze who last season scored 11 Ligue 1 goals for Lyon. In addition to this, Spurs loanee Manor Solomon could face his parent club. 

Solomon was a late arrival in the summer transfer window and did impress in Israel's recent 4-5 loss to Italy during the international break. However, Villarreal boss Marcelino Garcia Toral may opt to start the 26-year-old from the bench and deploy the winger as an impact sub if needed.  

Tottenham Hotspur vs Villarreal Predicted Lineups

  • Tottenham: Vicario, Porro, Romero, van de Ven, Udogie, Xavi Simons, Gray, Bergvall, Johnson, Kolo-Muani. Kudus 
  • Villarreal: Luiz Junior, Mourino, Foyth, Marin, Cardona, Buchanan, Comesana, Gueye, Moleiro, Pepe, Mikautuadze 

Tottenham vs Villarreal Odds

Tottenham are priced as favourites at 5/6 to win this game, with Villarreal the outsiders at 3/1. That gives the home team an implied win probability of 54.5% while a draw can be backed at 5/2. 

BTTS has been priced at 4/6 and over 2.5 goals is 8/11, while Randal Kolo-Muani is the favourite to score first at 9/2.  

Tottenham vs Villarreal TV & Live Stream:

Amazon Prime Video have chosen this match to be their live offering in Week 1 of the Champions League. Kick-off is set for 20:00.

Tottenham Hotspur vs Villarreal Stats

  • Both Tottenham and Villarreal have lifted the Europa League in the past five seasons 
  • The two teams have never met each other in a competitive game 

Randal Kolo-Muani to score anytime @ 6/4 

One of Daniel Levy's parting gifts to Tottenham was the capture of Randal Kolo-Munai and with the PSG loanee now calling the N17 postcode home for the rest of the season, the French international will look to make himself comfortable in his new surroundings. The best way to do that? Scoring goals as soon as possible.  

Admittedly manager Thomas Frank does have options in the centre forward position but with a talent like this at his disposal, it would be a surprise to see the 26-year-old only playing a cameo on Tuesday night. What would not come as a surprise, is seeing Kolo-Munai's name on the scoresheet. 

Tottenham Hotspur V Villarreal - Anytime Goal Scorer

Randal Kolo-Muani

Odds correct at time of publishing.

Tottenham to win to nil @ 11/5 

Although Tottenham's defensive line is unchanged in terms of names, there is already a different look and feel when it comes to playing style and if the pairing of Cristian Romero and Micky van de Ven can stay fit throughout the season, it may lead to a further positive outlook in the white half of North London. 

That partnership was key to Spurs' European glory in Bilbao back in May and it will be integral to any joy that Tottenham supporters are hoping to revel in on Tuesday. A rock solid backline allowing new attacking talent to flourish at the other end, makes a home win to nil look rather appealing.  

Tottenham Hotspur vs Villarreal - To Win to Nil

Tottenham Hotspur

Odds correct at time of publishing.

Tottenham Hotspur vs Villarreal Price Boosts

Tottenham Hotspur vs Villarreal - Price Boosts

G Mikautadze 1+ Shots on Target, N Pepe 1+ Shots on Target, Richarlison 1+ Shots on Target & X Simons 1+ Shots on Target

Odds correct at time of publishing.

Tottenham Hotspur vs Villarreal - Price Boosts

Tottenham to Win, X Simons to Score or Assist, Tottenham Most Corners & Villarreal Most Booking Points

Odds correct at time of publishing.

Tottenham Hotspur vs Villarreal - Price Boosts

Villarreal or Draw Double Chance, G Mikautadze to Score & Villarreal Most Booking Points

Odds correct at time of publishing.

Tottenham Hotspur vs Villarreal - Price Boosts

Richarlison 1+ Shots on Target, X Simons 1+ Shots on Target, C Romero to Commit 1+ Fouls & J Palhinha to Commit 1+ Fouls

Odds correct at time of publishing.

Tottenham Hotspur vs Villarreal - Price Boosts

Nicolas Pepe To Score At Anytime

Odds correct at time of publishing.

Tottenham Hotspur vs Villarreal - Price Boosts

Thomas Partey To Be Carded

Odds correct at time of publishing.

Tottenham Hotspur vs Villarreal - Price Boosts

Brennan Johnson To Score At Anytime

Odds correct at time of publishing.

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