Argentina vs South Africa Prediction: Boks to answer London calling

Potentially a bonus-point win away from retaining the Rugby Championship, South Africa will be looking to wrap up the title on Saturday (14:00, Sky Sports Mix) when they take on Argentina at Allianz Stadium.
Alex Jack provides his best bets in his Argentina vs South Africa prediction piece, as well as all the essential team news and match odds for the clash at Rugby HQ in London.
Argentina vs South Africa Betting Tips
- South Africa -16 handicap @ 11/10
*odds correct at time of publication
Team News
Argentina start with a front row of Mayco Vivas, skipper Julian Montoya and Joel Sclavi, with the second row consisting of Guido Petti and Pedro Rubiolo.
Pablo Matera, Marcos Kremer and Santiago Grondona complete the pack, with Simon Cruz Benitez and Geronimo Prisciantelli combining in the half-backs.
Santiago Chocobares and Justo Piccardo start in the centres, with Juan Cruz Mallia, Bautista Delguy and Santiago Carreras.
South Africa go with Ox Nche, Malcolm Marx and Thomas du Toit in the front row, with giants Eben Etzebeth and Ruan Nortje in the engine room.
Siya Kolisi will skipper the side from the back row alongside Pieter-Steph du Toit and Jasper Wiese.
Cobus Reinach and Sacha Feinberg-Mngomezulu start in the half-backs, with Damian de Allende and Canan Moodie in the centres.
The Springboks go with a back three of Ethan Hooker, Cheslin Kolbe and Damian Willemse.
Argentina vs South Africa Odds
Argentina are 7/1 to spoil the party and deny South Africa the title with victory at Allianz Stadium.
The Springboks are the heavy favourites at 1/11 for the win, while the draw at Twickenham is available at 20/1.
South Africa -16 handicap @ 11/10
Producing an impressive second-half display to romp to a 67-30 victory against the Pumas at Kings Park Stadium in Durban last weekend, it’s difficult to look past another comprehensive win for South Africa on Saturday.
Having put in two big performances against the Wallabies in Australia, it looks like Argentina have simply run out of steam.
Picking up wins against the All Blacks and Australia, there have certainly been positives for Argentina to take from this 2025 Rugby Championship campaign.
The Pumas won’t have the benefit of playing at home in this final game, with Allianz Stadium Twickenham hosting Saturday’s contest.
If this game was in Argentina, it would most likely be a closer contest, but with it being played on what should be a largely dry and overcast day in London, South Africa look to be more than capable of covering the handicap.
With a squad packed with big-time players used to performing in the crunch games, this Boks side look like they can break the South Africa hoodoo and retain a Rugby Championship or Tri Nations title for the first time in the country’s history.
Odds correct at time of publishing.
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