After their fairytale season last time out, Lens have endured a nightmare start to the new campaign, taking just a single point from five games in Ligue 1.
The French side will be hoping to turn that around on the Champions League stage as they visit Sevilla, who won the Europa League last season, on Wendesday night (20:00).
Sevilla’s central defenders Marcao and Tanguy Nianzou are expected to miss out through injury, joining goalkeeper Alfonso Pastor and Marcos Acuna in the treatment room.
However, both former Hertha Berlin striker Dodi Lukebakio and veteran defender Sergio Ramos made their debuts in the 1-0 weekend win over Las Palmas which lifted Los Rojiblancos off the foot of the fledgling La Liga stable.
They are both in contention for starts on Wednesday.
For the visitors, Jimmy Cabot, Wuilker Farinez, Nampalys Mendy and David Costa are all expected to miss out.
Versatile defender Facundo Medina does return from a suspension for the French side, however.
Sevilla to win to nil @ 21/10
Lens finished just a point off Paris Saint-Germain, the Ligue 1 title winners, last season.
However, their start to the campaign this time around could hardly have been worse.
After the departure of key men Louis Openda and Seko Fofana in the summer, Franck Haise’s side have lost four and drawn one of their opening five games.
To add to that, no side in the French top-flight has conceded as many goals as the Blood and Gold’s 11.
They visit a Sevilla team who have also not had the best start to the campaign, but who usually save their best for European competitions.
Jose Luis Mendilibar’s side won the Europa League last season and got their first win of the season last time out.
The Spaniards should be able to follow that up with another success without conceding against opponents who have failed to score in their last two matches.
With Lens struggling to stem the flow of goals they concede, they may also find it difficult to get on the scoresheet in this clash and Sevilla are fancied to win to nil.
Youssef En-Nesyri to score anytime @ 13/10
Sevilla’s Youssef En-Nesyri often produces big moments on the biggest stages and he has a rock-solid record in European football.
The Moroccan has eight goals in 14 Champions League appearances and could add to that tally in this match-up.
He has already opened his account in La Liga this season and, against a defence that has been struggling, En-Nesyri could once again make his mark on the European stage.