Inter Milan vs Juventus Prediction: More Derby d’Italia drama from San Siro

The second and final Derby d'Italia of the 2025/26 Serie A season takes place at San Siro on Saturday (19:45 GMT, live on Betfred.com). With Juventus coming from 3-2 down to win 4-3 in September's reverse meeting in Turin, you get the sense that Inter Milan will be desperate to exact revenge this weekend, especially as they look to maintain their healthy lead at the top of the table.

Below are my Inter Milan vs Juventus predictions, supported by all the latest team news and match odds.

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Team News

Denzel Dumfries (ankle), Nicolo Barella (muscle) and Hakan Calhanoglu (calf) all have chances of returning from injury for Cristian Chivu's Inter Milan on Saturday.

Football Odds

Juventus, meanwhile, are missing strikers Dusan Vlahovic (groin) and Arkadiusz Milik (unspecified), but otherwise, Luciano Spaletti has a full complement available.

Inter Milan vs Juventus Odds

Inter Milan are 19/20 favourites to end a three-game winless run against Juventus (D1, L2), implying a 51.3% probability of success, while Juventus are 3/1, or a 25% chance, to do the double over their rivals, with the stalemate priced at 12/5.

Betfred's Price Boosts include Lautaro Martinez To Have 3+ Shots On Target at 11/2 (was 9/2).

Both Teams To Score and Total Goals Over/Under +3.5 - Yes & Over 3.5 @ 13/5

Two of the last three head-to-heads have been blockbuster, with a 4-4 San Siro draw and 4-3 Juve win at Allianz Stadium sandwiched either side of 1-0 win for the Old Lady in Turin.

Goals have been plentiful for Inter of late, as they have thrashed Pisa 6-2 at home and Sassuolo 5-0 away in their last three league games, while January matches against Napoli (2-2) and Bologna (3-1) at San Siro each saw four strikes.

Today's Football Fixtures

Juve, meanwhile, have recorded big wins over Sassuolo (0-3), Cremonese (5-0), Napoli (3-0) and Parma (1-4) this calendar year, while they came from two goals down to draw 2-2 at home to Lazio last Sunday.

Given recent history, and the good goalscoring form both sides are in, I like the 13/5 price of both teams scoring in a game with at least four goals.

Booking Points Over/Under +37.5 - Over 37.5 @ 8/11

There is usually drama in the Derby D'Italia, and, often, plenty of cards to go around.

September's reverse fixture in Turin produced four yellow cards, amounting to 40 booking points, the same as last season's corresponding game in Milan.

Three of the last four head-to-heads have seen the over 37.5 booking points line land, and at this stage of the season, I can see the players and ref getting agitated on Saturday.