PSV vs Napoli Prediction: Goals galore in Eindhoven?

 | Tuesday 21st October 2025, 6:11am

Tuesday 21st October 2025, 6:11am

PSV Eindhoven welcome Napoli to the Philips Stadion on Tuesday evening (20:00 BST, live on TNT Sports 6) hoping to secure their first win of this season's Uefa Champions League campaign.

Tuesday's visitors are looking for their second win of the league phase, after losing to Manchester City at the Etihad Stadium on matchday one and beating Sporting Lisbon last time out. Read on for our PSV vs Napoli predictions, as well as the latest team news and match odds.

PSV vs Napoli Betting Tips

  • Over 3.5 goals @ 13/8
  • Double Chance - PSV or Draw @ 4/6

*odds correct at time of publication

Team News

The hosts could be without Kiliann Sildillia and Alassane Plea here, while Ruben van Bommel will be sidelined with a knee injury.

Ricardo Pepi and Eus Waayers are also both likely to miss out, but there should be a place in the starting XI for veteran winger Ivan Perisic as well as Guus Til, who scored both goals in PSV's 2-1 win over Go Ahead Eagles on Saturday.

As for Napoli, Rasmus Hojlund is expected to be absent with a thigh injury that kept him out of the weekend's defeat to Torino in Serie A.

Former PSV forward Noa Lang may be handed a start against his old side, but former Manchester United man Scott McTominay is struggling with an ankle issue, so his availability remains unclear.

Giovanni Di Lorenzo is available for selection after his European ban, while Romelu Lukaku continues to recover from a thigh injury.

PSV vs Napoli Predicted Lineups

  • PSV: Kovar; Dest, Obispo, Gasiorowski, Salah-Eddine; Junior, Schouten, Veerman; Man, Til, Perisic
  • Napoli: Meret; Di Lorenzo, Beukema, Buongiorno, Spinazzola; Gilmour; Neres, Anguissa, De Bruyne, Lang; Lucca

PSV vs Napoli Odds

The hosts are 11/5 for Tuesday's contest, giving them an implied win probability of 31.3%, while Napoli are 6/5 and the draw is a 13/5 chance.

Lorenzo Lucca currently leads the anytime goalscorer market at 6/4, and over 2.5 goals is available at 8/13.

PSV vs Napoli Stats

  • There have been 45 goals scored in PSV's last 11 Champions League matches
  • Napoli have lost their last three away clashes

Over 3.5 goals @ 13/8

Our first pick is focusing on the goal tally, and we think there'll be plenty of entertainment value on offer on Tuesday night.

There's been a whopping 45 goals across PSV's last 11 Champions League matches, and despite their injuries, this Napoli team have plenty of goals in them.

Both teams to score could also be a decent pick for Tuesday's contest, as it's landed in four of Napoli's last nine matches but at 8/15, there's very little value.

Over 3.5 goals landed in Napoli's victory over Pisa at the end of September, and it was also a winning play in PSV's recent tussles with Ajax and PEC Zwolle.

PSV vs Napoli - Total Goals
Over 3.5

Odds correct at time of publishing.

Double Chance - PSV or Draw @ 4/6

Our second pick is Double Chance - PSV or Draw, mainly due to injuries to this Napoli side.

McTominay, who's been a revelation since joining the Italian giants, as well as a massive goal threat, will likely be sidelined for Tuesday's encounter. Similarly, Hojlund has rediscovered his shooting boots since joining on loan from Manchester United, and has scored seven goals across eight Champions League appearances to date, will also be absent for the visitors. That's plenty of firepower that will be missing.

In addition, Napoli have suffered three-straight away defeats for the first time in two years, so this bet feels like a sensible pick ahead of what is sure to be an entertaining affair.

PSV vs Napoli - Double Chance
PSV or Draw

Odds correct at time of publishing.

Offers

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