NFL Week 10 Predictions: Straight Up & Against the Spread Picks for Every Game

Week 9 of the season didn't go too badly for our NFL tipsters...
Straight up, everybody went at least 7-7, so there were no losing records this week, with Alan, Adam and Jonny all scoring 9-5. When picking looking Against the Spread, Jonny came out on top going 8-6, with Neil and Alan both following closely at 7-7.
Four teams have a bye this week, so there are 14 games to cover including the second match in Germany - that game takes place in the 14:30 GMT window.
For our full season-long record check out the bottom of the article. Please read on for all of our NFL Week 10 Picks & Predictions...
*Odds accurate as of 09:00, Wednesday 8 November, 2023
Bye Teams: Dolphins, Rams, Chiefs & Eagles.
Week 10 NFL Picks & Predictions:
Friday - 01:15AM:
Game 1: Panthers (+3.5) @ Bears
Picks ATS:
- Adam: Bears
- Alan: Bears
- Jonny: Bears
- Neil: Panthers
Money Line: Bears 8/15 & Panthers 6/4
Picks Straight Up:
- Adam: Bears
- Alan: Bears
- Jonny: Bears
- Neil: Panthers
Comments: Two poor sides face off in Chicago as the 2-7 Bears host the 1-7 Panthers. The Windy City side could be boosted by the return of Justin Fields at quarterback, after his layoff with a troubling thumb injury.
Meanwhile, Carolina continue to struggle, as does #1 draft pick Bryce Young, who has almost as many interceptions as TD's this season.
The Panthers have conceded an average of 36.2 points on their four road losses and I expect the Bears to cover the spread here fairly comfortably - Adam
Sunday - 14:30 (in Germany):
Game 2: Colts (-1.5) @ Patriots
Picks ATS:
- Adam: Colts
- Alan: Patriots
- Jonny: Colts
- Neil: Colts
Money Line: Colts 4/5 & Patriots 21/20
Picks Straight Up:
- Adam: Colts
- Alan: Patriots
- Jonny: Colts
- Neil: Colts
Comments: The decision for the Pats to move on from Tom Brady back in 2019 looks to be getting worse and worse as the weeks go by for New England and Bill Belichick.
Simply put, his team can't win games and last week they lost to a Commanders team that isn't even trying to win after trading away two of their defensive stars at the trade deadline.
Belichick has never lost in Europe but I think that comes to an end this weekend. - Jonny
Sunday - 18:00:
Game 3: Browns (+5.5) @ Ravens
Picks ATS:
- Adam: Browns
- Alan: Ravens
- Jonny: Ravens
- Neil: Ravens
Money Line: Ravens 4/11 & Browns 11/5
Picks Straight Up:
- Adam: Ravens
- Alan: Ravens
- Jonny: Ravens
- Neil: Ravens
Comments: The AFC North is turning into a bloodbath. Heading into Week 10, all four teams are two games above .500, which makes this showdown all the more intriguing.
The Browns will also be bringing the NFL's best defense to this game, while the Ravens come into this one off the back sticking 37 points past Seattle.
I feel like this game will be decided by who plays better between Lamar Jackson and Deshaun Watson and I'll take Jackson in that debate. - Jonny
Game 4: Texans (+7.5) @ Bengals
Picks ATS:
- Adam: Texans
- Alan: Bengals
- Jonny: Bengals
- Neil: Bengals
Money Line: Bengals 3/10 & Texans 5/2
Picks Straight Up:
- Adam: Bengals
- Alan: Bengals
- Jonny: Bengals
- Neil: Bengals
Comments: The Bengals are kicking into gear at just the right time after a really poor start to the season. Joe Burrow appears to have his mobility and his mojo back and Cincy have won five straight games. However, they still remain bottom of the powerhouse AFC North and will need to keep winning to gain a strong position going into the playoffs.
It couldn't really be a worse time then to play the Texans, who are showing they have got a bit about themselves this year, in particular in the form of rookie QB CJ Stroud. The #2 draft pick has been magnificent thus far and went to a new level in week 9, leading his side to a dramatic comeback win on the back of a 470 yard, Five touchdown performance - a record for a rookie in the NFL.
I'm taking the Bengals to win this one but the Texans to keep it close - Adam
Game 5: 49ers (-3.5) @ Jaguars
Picks ATS:
- Adam: Jaguars
- Alan: Jaguars
- Jonny: 49ers
- Neil: 49ers
Money Line: 49ers 8/13 & Jaguars 13/10
Picks Straight Up:
- Adam: Jaguars
- Alan: Jaguars
- Jonny: 49ers
- Neil: 49ers
Comments: These two teams are in complete contrasting form.
One one hand, the Jags are the hottest team in the NFL and currently on a five-game winning streak, and on the other we have the 49ers, who haven't won a match since Week 5.
To be fair, the 49ers' biggest issue during their three-game losing streak has been injuries, but both teams are coming off a bye week, which San Francisco desperately needed.
The Niners have added Chase Young to the ranks, who should provide a boost to the pass-rushing game, and I do believe the 49ers offense will thrive here. - Jonny
Game 6: Saints (-2.5) @ Vikings
Picks ATS:
- Adam: Vikings
- Alan: Vikings
- Jonny: Vikings
- Neil: Saints
Money Line: Saints 20/29 & Vikings 6/5
Picks Straight Up:
- Adam: Vikings
- Alan: Vikings
- Jonny: Vikings
- Neil: Saints
Comments: Both sides come into this NFC battle with a 5-4 record and this game could be crucial in deciding who makes the playoff places.
After the loss of QB Kirk Cousins for the season, the Vikings brought in Joshua Dobbs as back-up but he was needed far sooner than expected in week 9. The 28-year-old has bounced around the league but showed his tremendous talent on Sunday, virtually winning the game by himself, with two TD passes and a rushing TD to ice the game.
Meanwhile, the Saints are trudging along with the dual QB threat of Derek Carr and Taysom Hill giving them options in the redzone. They've won their last two games but this will be a much tougher challenge than last week.
I'm taking the Vikings, under Dobbs, to keep up the momentum here - Adam
Game 7: Packers (+3.5) @ Steelers
Picks ATS:
- Adam: Steelers
- Alan: Packers
- Jonny: Packers
- Neil: Steelers
Money Line: Steelers 4/7 & Packers 7/5
Picks Straight Up:
- Adam: Steelers
- Alan: Packers
- Jonny: Packers
- Neil: Steelers
Comments: Two legendary franchises square up in Acrisure Stadium, formerly Heinz Field. Home field advantage could be key, as there's relatively little to choose between them in my book.
Both are unconvincing overall - and unless one of the QBs gets hot, I'm not sure this one is likely to be first up on Match of the Day, proverbially, but let's hope I'm wrong. Small stakes on the under (around 38.5) - Alan
Game 8: Titans (+1.5) @ Buccaneers
Picks ATS:
- Adam: Titans
- Alan: Buccaneers
- Jonny: Buccaneers
- Neil: Titans
Money Line: Buccaneers 10/11 & Titans 10/11
Picks Straight Up:
- Adam: Titans
- Alan: Buccaneers
- Jonny: Buccaneers
- Neil: Titans
Comments: You can have 250/1 about either of these sides lifting the Super Bowl in February, which is not I'm sure how they hoped they'd be viewed by the layers as November hits its straps.
Identical 3-5 records tells its own tale, but the Bucs look slightly more potent on offense, arguably. Fiendishly tricky to figure - another small stakes job - Alan
Sunday - 21:05:
Game 9: Falcons (-1.5) @ Cardinals
Picks ATS:
- Adam: Falcons
- Alan: Falcons
- Jonny: Falcons
- Neil: Cardinals
Money Line: Falcons 4/5 & Cardinals 21/20
Picks Straight Up:
- Adam: Falcons
- Alan: Falcons
- Jonny: Falcons
- Neil: Cardinals
Comments: The Cards are a woeful 1-8, while the Falcons stand at a more respectable 4-5. It's in Arizona, hence I guess the slim spread, but really the Falcons should be covering and might just about be the bet of the weekend for me (famous last ..)
The reverses Atlanta have suffered have often been narrow ones and the visitors can prevail here - Alan
Game 10: Lions (-2.5) @ Chargers
Picks ATS:
- Adam: Lions
- Alan: Chargers
- Jonny: Chargers
- Neil: Lions
Money Line: Lions 8/11 & Chargers 23/20
Picks Straight Up:
- Adam: Lions
- Alan: Chargers
- Jonny: Lions
- Neil: Lions
Comments: This is an interesting one, with the Lions coming off a bye week and the Chargers off the back of a short week, having beaten the Jets on Monday Night Football.
Detroit are 3-1 on the road this season and will be confident of picking up another scalp on their west coast road trip. They have RB David Montgomery back, who should cause big problems for the LA defense and this could come down to a shootout between Jared Goff and Justin Herbert.
I like Dan Campbell's side to win this one in a high scoring, close battle - Adam
Sunday - 21:25:
Game 11: Giants (+15.5) @ Cowboys
Picks ATS:
- Adam: Cowboys
- Alan: Giants
- Jonny: Cowboys
- Neil: Cowboys
Money Line: Cowboys 1/14 & Giants 17/2
Picks Straight Up:
- Adam: Cowboys
- Alan: Cowboys
- Jonny: Cowboys
- Neil: Cowboys
Comments: I feel like the Giants' season so far has been eerily similar to Manchester United's in the Premier League.
They both enjoyed promising campaigns under new head coaches last year, which brought some success back to the club, but they have since failed to build upon that, and now things appear to be unravelling at an alarming rate.
Daniel Jones appears to be out until the end of the season after suffering an ACL tear in Week 9, and the Cowboys have been excellent at home this season.
Despite this being a rivalry clash, I see no hope for the G-Men here. - Jonny
Game 12: Commanders (+6.5) @ Seahawks
Picks ATS:
- Adam: Commanders
- Alan: Seahawks
- Jonny: Seahawks
- Neil: Commanders
Money Line: Seahawks 4/11 & Commanders 11/5
Picks Straight Up:
- Adam: Seahawks
- Alan: Seahawks
- Jonny: Seahawks
- Neil: Commanders
Comments: Metcalfe, Lockett and company were becalmed at weekend for the 'Hawks, and Geno threw an interception but no TDs. Washington are suffering in a white-hot NFC East with the Eagles and Cowboys to contend with, while Seattle pop along nicely in the West tying with the inconsistent 49ers. They can resume winning ways.
Home comforts - Seattle for me - Alan
Monday - 01:20:
Game 13: Jets (-1.5) @ Raiders
Picks ATS:
- Adam: Raiders
- Alan: Jets
- Jonny: Raiders
- Neil: Raiders
Money Line: Jets 5/6 & Raiders EVS
Picks Straight Up:
- Adam: Raiders
- Alan: Jets
- Jonny: Jets
- Neil: Raiders
Comments: Basement stuff - 66/1 and 250/1 respectively for Super Bowl - but I was daft enough to tip up the Jets last week and I'm going to do exactly the same this.
Still like coach Rob Saleh, but need QB Zach Wilson, filling Aaron Rodgers' shoes (who could?), to do better. This is an eminently winnable affair for the 4-4 New Yorkers.
Tuesday - 01:15:
Game 14: Broncos (+7.5) @ Bills
Picks ATS:
- Adam: Bills
- Alan: Bills
- Jonny: Bills
- Neil: Bills
Money Line: Bills 1/4 & Broncos 3/1
Picks Straight Up:
- Adam: Bills
- Alan: Bills
- Jonny: Bills
- Neil: Bills
Comments: Another interesting looking matchup takes place on Monday Night Football, with the Bills looking to overturn their disappointing loss to the Bengals, in Sundays primetime showdown in week 9. Now they take on the Broncos, who are coming off a bye week, on the back of back-to-back wins, including over the Super Bowl champions, the Kansas City Chiefs.
Buffalo are 4-0 at home and should have enough to win this one but they are not clicking offensively and Denver have shown improvement. I'll take the Bills to just cover the spread - Adam
Season Records:
Against the Spread:
- Adam: 64-72
- Alan: 70-66
- Jonny: 72-64
- Neil: 72-64
Straight Up:
- Adam: 78-58
- Alan: 86-50
- Jonny: 80-56
- Neil: 78-58
Remember to check out our NFL Betting Tips index page where we preview games live on Sky Sports along with this weekly column...




















