The San Francisco 49ers will attempt to get off to a 3-0 start when they welcome the New York Giants to the Levi’s Stadium on Thursday night (01:15 Friday morning UK time).

San Francisco have now won 12 consecutive regular-season games after their 30-23 victory over the Los Angeles Rams on Sunday, while the Giants stormed back from a 21-point deficit against the Arizona Cardinals to avoid an 0-2 start.

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For the Niners, wide receiver Brandon Aiyuk is still dealing with the shoulder injury he sustained on his first catch against the Los Angeles Rams this past weekend while cornerback Ambry Thomas is working through a knee injury. Both players were listed as limited participants on Tuesday.

As for the Giants, the big miss for them will be Saquon Barkley, who is expected to miss around three weeks of action due to an ankle injury.

The Giants lost starting left guard Ben Bredson to a concussion in Week 2 while left tackle Andrew Thomas was inactive with a hamstring injury, but both could return for the trip to San Francisco.

San Francisco 49ers (-10.5) @ 10/11

I’m siding with San Francisco to cover the spread here.

New York have been poor in defense, allowing opponents almost 0.6 points per play — which is the league’s worst.

San Francisco boast the NFL’s best rush attack, and have covered the spread in nine of their last 10 games as a home favourite. Even if Brandon Aiyuk doesn’t feature, I just can’t see the Giants back line keeping out the likes of Christian McCaffrey, George Kittle and Deebo Samuel.

The Niners have also shown how dominant their defense can be, particularly in the Week 1 clash with the Steelers, and with Saquon Barkley out injured, it’s hard to see where the Giants can trouble the San Francisco defense.

The 49ers have scored 30 or more points in all but one of Brock Purdy’s seven regular-season starts. The fact they’re at home against a Giants defense that just surrendered a big offensive output to the Cardinals is even more encouraging for Kyle Shanahan.

New York Giants under 15 points @ 5/4

As mentioned, I think the absence of Barkley is a huge miss for New York, particularly as he was at the forefront of the comeback against Arizona in Week 2.

I fail to see where the points will come from for Big Blue, and New York have scored 16 or fewer points in five out of nine losses dating back to last season, and three out of five on their travels.

The Niners defence is arguably the best in the league with one of the best pass-rushers in Nick Bosa, who is still looking to record his first sack of the season and he’s got a great chance of getting it against Daniel Jones, who has been sacked 10 times.

Barkley is the bulk of the Giants’ firepower, in my opinion, so I’m taking them to score under 15 points.